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Vol.59 No.3 contents | Japanese/English |
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- Case Report -
Primary Lung Adenocarcinoma Revealed in a Case of Metastatic Thyroid Tumor
Hideyuki Itoigawa1, Koichiro Shima1, Taro Tanaka1, Masashi Yamamoto1, Norio Takahashi2, Tatsunari Satake31Department of Respiratory Medicine, 2Department of Endocrinology and Metabolism, 3Department of Pathology, Nagoya Ekisaikai Hospital, Japan
Background. Primary lung cancer metastasis to the thyroid is extremely rare. We report the case of a patient in whom primary lung cancer was detected due to a metastatic thyroid tumor, along with discussion of the relevant literature. Case Report. A 68-year-old woman presented with anterior cervical pain. Bilateral thyroid enlargement was identified on chest computed tomography (CT). A fine-needle aspiration (FNA) biopsy of the thyroid showed malignant cells. Chest CT demonstrated a right lower lobe pulmonary nodule and mediastinal lymphadenopathy. A transbronchial biopsy was performed, and a pathological examination revealed lung adenocarcinoma; these findings correlated with the cytological findings on a thyroid FNA biopsy. Therefore, a diagnosis of primary lung adenocarcinoma metastasis to the thyroid was made. Erlotinib was administered due to the patient's positive epidermal growth factor receptor (EGFR) mutation status, following which the size of the lung and thyroid tumors decreased. Conclusion. In our patient, lung adenocarcinoma with multiple brain metastases was revealed due to a thyroid metastasis; the patient's condition improved after the administration of a tyrosine kinase inhibitor for EGFR.
key words: Primary lung cancer, Metastatic thyroid tumor, Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)
Received: February 8, 2019
Accepted: April 2, 2019
JJLC 59 (3): 270-275, 2019
