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Vol.59 No.3 contents | Japanese/English |
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- Case Report -
Primary Mediastinal Germ Cell Tumor Successfully Treated with Chemotherapy Followed by Surgery: a Case Report
Hiroyuki Tsuchida1, Masayuki Tanahashi1, Haruhiro Yukiue1, Eriko Suzuki1, Naoko Yoshii1, Hiroshi Niwa11Division of Thoracic Surgery, Respiratory Disease Center, Seirei Mikatahara General Hospital, Japan
Background. Primary mediastinal germ cell tumors are rare. The mainstay of treatment is systemic chemotherapy. Surgical resection of the residual tumor is considered for patients with normalized tumor marker levels. Case. The patient was a 49-year-old man with an anterior mediastinal tumor that had been identified by chest computed tomography (CT). His serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA), and human chorionic gonadotropin (hCG) levels were elevated. A primary mediastinal mixed germ cell tumor was diagnosed based on the results of a CT-guided biopsy. Four cycles of bleomycin, etoposide and cisplatin combination chemotherapy (BEP) were administered. As the serum CEA, CYFRA, and hCG levels declined to normal and the tumor size diminished, residual tumor resection was conducted. The tumor was completely removed with the superior vena cava (SVC) and the SVC was reconstructed with a polytetrafluoroethylene (PTFE) graft. Rescue chemotherapy was administered after the detection of a small amount of viable cells (Ef.2) in the resected tumor. At the time of writing, tumor recurrence has not been detected for more than 4 months after surgery. Conclusion. We experienced a case of primary mediastinal germ cell tumor that was completely surgically resected after chemotherapy.
key words: Primary mediastinal germ cell tumor, Non-seminoma, BEP, Viable cell, Complete resection
Received: November 1, 2018
Accepted: April 3, 2019
JJLC 59 (3): 276-281, 2019
