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Vol.60 No.5 contents Japanese/English

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Article in Japanese

- Invited Review Article -

Respiratory Cytology Update -Utilization and Issues for Diagnoses and Biomarkers-

Dai Sonoda1, Yukitoshi Satoh1
1Department of Thoracic Surgery, Kitasato University School of Medicine, Japan

Recent developments in molecular-targeted therapies and immunotherapies have greatly expanded treatment options for respiratory tumors. In cases of inoperable cancer or postoperative recurrence, the tissue type and presence or absence of gene mutation must be evaluated in order to determine treatment strategies. However, because of the anatomical characteristics of respiratory organs, it is often difficult to collect specimens. In some preoperative or inoperable cases, sufficient tissue specimens cannot be obtained, and the specimens collected are only cytologic samples. Therefore, the collection of high-quality samples is an important issue. In recent years, the development of examination methods (e.g. a rapid on-site cytologic evaluation) and cell preservation techniques (e.g. cell block and liquid-based cytology) has dramatically improved clinicians' ability to make cytological diagnoses based on respiratory specimens. In addition, next generation sequencing has greatly expanded the range of applications for cytological specimens; this technique can be used not only for making a diagnosis but also for detecting genetic abnormalities and is therefore useful for determining treatment strategies.
key words: Respiratory organ, Cytology, Biomarker

JJLC 60 (5): 373-378, 2020

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