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Vol.60 No.7 contents | Japanese/English |
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- Original Article -
A Retrospective Single-Institutional Analysis of the Usefulness of Pleural Effusion-Cell Block for Diagnosing Malignant Pleural Mesothelioma
Masaki Hashimoto1, Michiko Yuki2, Toru Nakamichi1, Akifumi Nakamura1, Ayumi Kuroda1, Seiji Matsumoto1, Nobuyuki Kondo1, Ayuko Sato2, Tohru Tsujimura2, Seiki Hasegawa11Department of Thoracic Surgery, 2Division of Molecular Pathology, Department of Pathology, Hyogo College of Medicine, Japan
Objective. The pleural effusion-cell block procedure has recently been recognized as an effective tool for diagnosing malignant pleural mesothelioma (MPM). We retrospectively analyzed the usefulness of pleural effusion-cell block for diagnosing MPM in our institution. Patients and Methods. Forty-four patients who underwent a video-assisted thoracoscopic pleural biopsy due to suspicion of MPM between January 2018 and December 2018 were enrolled in this retrospective study. We compared the results of a preoperative cytological examination, including cell block, with those of a pathological examination by a pleural biopsy. Results. Of the 44 patients, 25 preoperatively underwent a cytological examination, including the cell block procedure. The cytological examination revealed malignant cells suspected of being MPM in 18 patients, atypical cells in 3 patients and no malignant cells in 4 patients. A pathological examination by a pleural biopsy revealed MPM in 22 patients, including 3 patients in whom a cytological examination revealed atypical cells and 1 in whom a cytological examination revealed no malignant cells. The sensitivity, specificity and positive and negative predictive values of the cytological examination in this study were 81.8% (18/22), 100% (3/3) and 100% (18/18) and 42.9% (3/7), respectively. Conclusions. Our findings suggest that a cytological examination with the cell block procedure is useful for diagnosing MPM.
key words: Malignant pleural mesothelioma, Pleural biopsy, Pleural effusion cytology, Cell block
Received: April 21, 2020
Accepted: September 14, 2020
JJLC 60 (7): 972-978, 2020
