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Vol.61 No.3 contents | Japanese/English |
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- Case Report -
A Case of Granulocyte Colony-stimulating Factor-producing Pulmonary Pleomorphic Carcinoma with Metastasis to the Small Intestine in Which Surgery and Bevacizumab-based Chemotherapy Were Effective
Takehiro Tsuchiya1, Atsushi Sano1, Takuma Yotsumoto1, Toshinori Tsukahara2, Tsutomu Fukuda21Department of Thoracic Surgery, 2Department of Respiratory Medicine, Chigasaki Municipal Hospital, Japan
Background. Granulocyte colony-stimulating factor (G-CSF)-producing tumor is associated with leukocytosis and a poor prognosis. Case. The comprehensive evaluation of a 55-year-old woman revealed a right upper lobe mass with chest wall infiltration and leukocytosis. A histological examination following right upper lobectomy with chest wall resection revealed G-CSF-producing pulmonary pleomorphic carcinoma. Her disease was judged to be pathological stage IIB (T3bN0M0). Leukocytosis persisted after the surgery for two months. A further examination revealed wall thickening limited to the small intestine, so enterectomy was performed, which revealed a metastatic lesion. Leukocytosis was subsequently normalized. We administered four courses of systemic chemotherapy consisting of carboplatin, paclitaxel, and bevacizumab. In addition, we administered bevacizumab-based maintenance chemotherapy for 50 cycles. Although G-CSF-producing lung carcinomas are associated with poor prognoses, she remained free of recurrence for five years after surgery. Conclusion. In the present case, surgery and bevacizumab-based systemic and maintenance chemotherapy may have been effective against G-CSF-producing pulmonary pleomorphic carcinoma.
key words: Granulocyte colony-stimulating factor (G-CSF), Lung cancer, Pleomorphic carcinoma, Surgery, Chemotherapy
Received: October 22, 2020
Accepted: January 18, 2021
JJLC 61 (3): 177-183, 2021
