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Vol.61 No.3 contents | Japanese/English |
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- Case Report -
Relapse of Paraneoplastic Syndrome with Rheumatoid Symptoms (Carcinomatous Polyarthritis) After the Administration of Durvalumab
Yoshio Nakano1, Yusuke Kuze1, Takuya Takaiwa1, Gen Masuda1, Koji Nishida1, Kayo Kusama1, Chihiro Nishio1, Iwao Gohma11Department of Respiratory Medicine, Sakai City Medical Center, Japan
Background. The administration of an immune checkpoint inhibitor (ICI) to patients with rheumatoid arthritis worsens joint symptoms. No study has focused on carcinomatous polyarthritis (CP), which develops as a paraneoplastic syndrome-like symptom of rheumatoid arthritis, recurring after the administration of an ICI. Case. A 50-year-old man had joint pain from August X and was referred to our hospital for suspected rheumatoid arthritis in October X. The patient had multiple joint pain without joint swelling or hot sensation. He was diagnosed with left upper lobe lung adenocarcinoma and underwent left upper lobectomy and lymph node dissection in December X. After surgery, the joint pain resolved without any treatment; therefore, the patient was diagnosed with paraneoplastic syndrome. Furthermore, he was diagnosed with lung cancer recurrence and received chemoradiotherapy in November X+1. After chemoradiotherapy, the patient received durvalumab in January X+2. After the administration of durvalumab twice, the joint pain recurred, being considered relapse of CP. The symptoms improved after the oral administration of a steroid, and durvalumab was able to be continued. Conclusion. Relapsed symptoms were observed in a patient with CP following durvalumab administration; however, durvalumab was able to be continued following steroid administration.
key words: Lung adenocarcinoma, Paraneoplastic syndrome, Carcinomatous polyarthritis, Immune checkpoint inhibitors
Received: January 20, 2021
Accepted: February 25, 2021
JJLC 61 (3): 208-212, 2021
