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Vol.61 No.5 contents | Japanese/English |
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- Case Report -
A Case of Squamous Cell Carcinoma with Foci of Adenocarcinoma with Confirmed Metastatic Recurrence of the Adenocarcinoma Component
Hideto Oshita1,3, Tatsuki Takahashi1, Misato Senoo1, Kunihiko Funaishi1, Makoto Fujiwara2, Yasuyuki Mitama1, Ken Okusaki11Department of Internal Medicine, 2Department of Respiratory Surgery, Mihara Medical Association Hospital, Japan, 3Department of Respiratory Medicine, Yoshijima Hospital, Japan
Background. Adenosquamous carcinoma is a relatively rare lung cancer, and reports of borderline cases that do not meet the diagnostic criteria of adenosquamous carcinoma are even rarer. Case. A man in his 60s with a history of smoking underwent lobectomy for a cavitous tumor in the upper lobe of the left lung. The resected tumor was 95% non-keratinizing squamous cell carcinoma and 5% papillary adenocarcinoma, and consequently, he was diagnosed with squamous cell carcinoma with foci of adenocarcinoma. Fluorodeoxyglucose-positron emission tomography (FDG-PET) performed three years and five months after lobectomy revealed the accumulation of FDG in the left axillary lymph node and thoracic vertebra. Only papillary adenocarcinoma was histopathologically confirmed in the resected lymph node. This patient was treated with carboplatin/pemetrexed/pembrolizumab combination therapy and exhibited a significant response. Conclusion. As a result, even adenosquamous carcinoma with a small proportion of adenocarcinoma components requires attention due to metastasis.
key words: Adenosquamous lung carcinoma, Adenocarcinoma, Squamous cell carcinoma, Postoperative recurrence
Received: February 5, 2021
Accepted: May 17, 2021
JJLC 61 (5): 402-406, 2021
