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Vol.61 No.5 contents | Japanese/English |
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- Case Report -
A Case of Advanced Non-small Cell Lung Cancer with Visual Impairment due to Dural Metastasis
Yuiko Masuda1, Shinji Iyama1, Shiho Ishizuka1, Kimitaka Akaike1, Aiko Masunaga1, Yusuke Tomita1, Takuro Sakagami11Department of Respiratory Medicine, Kumamoto University Hospital, Japan
Background. Cases of visual impairment associated with lung cancer are relatively rare. We herein report a case of advanced non-small cell lung cancer with left eye blindness due to dural metastasis near the anterior clinoid process. Case. A 78-year-old woman was admitted to our hospital, because of left visual impairment and cough. CT revealed a soft tissue mass with a major axis of approximately 6 cm along the left lower lobe bronchus and multiple lymphadenopathies in the mediastinum and left hilum. Brain-enhanced MRI showed dural metastasis in contact with the meninges near the left anterior clinoid process of the cranial base, which was considered to be the cause of her visual impairment. She was diagnosed with lung adenocarcinoma cT3N3M1c stage IVB as a result of systemic examination, and was positive for EGFR gene mutation (exon 19 deletion). The patient received therapy with osimertinib (80 mg/day) and underwent stereotactic radiotherapy (30 Gy/15 Fr). Osimertinib treatment was not associated with any serious adverse events and resulted in the improvement of her vision. Imaging findings showed a partial response. Conclusion. Osimertinib and stereotactic radiotherapy were effective for advanced non-small cell lung cancer that led to blindness due to dural metastasis, and visual recovery was obtained.
key words: Lung adenocarcinoma, Dural metastasis, Visual impairment, EGFR gene mutation
Received: March 16, 2021
Accepted: June 2, 2021
JJLC 61 (5): 423-428, 2021
