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Vol.63 No.1 contents | Japanese/English |
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- Case Report -
A Case of Malignant Pleural Mesothelioma Recurring 10 Years After a Long-term Response to Chemotherapy
Keisuke Hashida1, Kojiro Otsuka1, Yuya Tanaka1, Takashi Inao1, Kazuya Monden1, Taiki Masuya1, Takashi Tashiro2, Rieko Ito2, Yujiro Suzuki11Respiratory Center, 2Department of Pathology, Shinko Hospital, Japan
Background. Malignant pleural mesothelioma, an asbestos exposure-related disease, continues to have a poor prognosis despite advances in treatment options, such as the advent of immune checkpoint inhibitors, in recent years. However, there have been reports of long-term survivors, and the course of the disease is diverse. We herein report a patient who relapsed 10 years after a long-term response to a single chemotherapy regimen following the diagnosis. Cases Description. A 90-year-old man was referred to our hospital in X−10 with a diagnosis of epithelial-type malignant pleural mesothelioma (cT1N0M0 stage IA) by a thoracoscopic biopsy after presenting with symptoms of dyspnea on exertion. After four courses of chemotherapy with carboplatin and pemetrexed, the patient achieved long-term remission. Chest computed tomography performed in year X revealed enlarged mediastinal lymph nodes and a subcutaneous nodule on the right side of the chest. The subcutaneous nodule was visually consistent with the site of prior thoracoscopic insertion at the time of the first medical examination. A biopsy of the same site was performed, and a diagnosis of recurrence was made. Conclusion. Among patients with malignant pleural mesothelioma with a poor prognosis, this case showed a good response to chemotherapy and a long-term progression-free survival. However, it may be necessary to follow these patients up with a low threshold to suspect recurrence.
key words: Malignant pleural mesothelioma, Chemotherapy, Long-term response, Recurrence
Received: April 13, 2022
Accepted: September 8, 2022
JJLC 63 (1): 45-51, 2023
