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第45巻第6号目次 | Japanese/English |
 | Full Text of PDF (111K) Article in Japanese |
─ 症例 ─
A Resected Case of Pulmonary Large Cell Neuroendocrine Carcinoma Showing Aggressive Progression
Satoshi Shiono1, Kanji Nagai1, Junji Yoshida1, Mitsuyo Nishimura1, Genichiro Ishii2, Yutaka Nishiwaki11Department of Thoracic Oncology, National Cancer Center Hospital East, Japan, 2Pathology Division, National Cancer Center Research Institute East, Japan
Background. In 1991, Travis et al. proposed a new category of large cell neuroendocrine carcinoma (LCNEC). Some investigators reported poor prognosis of LCNEC patients, with 5-year survival rates similar to small cell carcinoma. We report a case of LCNEC with aggressive progression after complete resection. Case. A 71-year-old man underwent left pneumonectomy and lymph node dissection for lung cancer on June 13, 2002. No finding suggested distant metastasis. The pathological diagnosis was large cell neuroendocrine carcinoma, T2N1M0, stage IIB. Two months after surgery, he presented with lumbago. Bone scintigram and magnetic resonance imaging revealed bone metastasis to the right sacroiliac joint. A brain metastasis was also detected by computed tomography. He received 30-Gy brain irradiation and 30-Gy bone radiotherapy to relieve the pain. Although the radiotherapy alleviated the pain, the brain and sacroiliac joint metastases did not shrink. The patient died of recurrent lung cancer 99 days after the surgical resection. Conclusion. We reported an aggressive progression case of pulmonary LCNEC. Prognosis and treatment efficacy in LCNEC patients remain controversial, and further investigation is needed.
索引用語：Large cell neuroendocrine carcinoma (LCNEC), Lung cancer, Surgery
受付日：2005年2月17日
受理日：2005年8月17日
肺癌 45 (6)：751─754，2005
