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第59巻第4号目次 | Japanese/English |
 | Full Text of PDF (1290K) Article in Japanese |
─ 症例 ─
Case Report: Stiff Person Syndrome with Thymoma
Takumi Sonokawa1,4, Hirohiko Shizukawa2, Shin Ichihara3, Shunji Muraoka3, Jitsuo Usuda4, Koichi Tanaka11Department of Surgery, 2Department of Neurology, 3Department of Pathology, Sapporo-Kosei General Hospital, Japan, 4Department of Thoracic Surgery, Nippon Medical School Hospital, Japan
Background. Stiff person syndrome is a rare neurological syndrome characterized by fluctuating muscle rigidity and painful spasms. About 5-8％ of stiff person syndrome cases are associated with malignant tumors, and the symptoms can manifest as a paraneoplastic disorder. Case. We herein report a 68-year-old man who was referred to our hospital with a chief complaint of gait disturbance due to painful muscle rigidity in both legs. Examinations of the head and spine showed no abnormalities. However, on chest computed tomography, an anterior mediastinal tumor was seen, and blood tests showed a high titer of anti-glutamic acid decarboxylase antibody. These findings suggested that his symptoms could be attributed to paraneoplastic neurological syndrome associated with the mediastinal tumor. Furthermore, characteristic symptoms and laboratory findings also indicated stiff person syndrome. These symptoms were not affected by initial treatment with steroids, but they were improved by benzodiazepine and baclofen treatment. The pathological diagnosis after radical thymectomy was type B2 thymoma. The patient's postoperative course was uneventful. His medications were decreased, and his symptoms gradually improved. Conclusion. Thymectomy might offer symptomatic relief for stiff person syndrome associated with thymoma.
索引用語：Stiff person syndrome, Thymoma, Paraneoplastic neurological syndrome, Anti-glutamic acid decarboxylase antibody
受付日：December 26, 2018
受理日：May 7, 2019
肺癌 59 (4)：360─365，2019
