The Journal of the Japanese Respiratory Society ONLINE JOURNAL
ABSTRACT
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Article in Japanese
Original Article
The preventive effect of 23-valent pneumococcal polysaccharide vaccine against drug-resistant Streptococcus pneumonia in patients with chronic respiratory disease
Nobuaki Kobayashi1), Yuji Watanuki1), Naoki Miyazawa1), Makoto Kudo1), Satoshi Inoue1), Takashi Sato1), Kei Mishina1), Hiroshi Takahashi2), Takeshi Kaneko3) and Yoshiaki Ishigatsubo4)
1)Department of Respiratory Medicine, Yokohama City University Hospital
2)Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center
3)Respiratory Center, Yokohama City University Medical Center
4)Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
ABSTRACT
Objective: To elucidate the preventive effect of 23-valent pneumococcal polysaccharide vaccine (PV) on drug-resistant Streptococcus pneumoniae. Methodology: Participants (outpatients, over 60 years of age, and with chronic lung disease) were interviewed and divided into two groups: the PV-vaccinated group (n=722) and the non-vaccinated group (n=872). The antimicrobial susceptibility and the genotype of antibiotic-resistant genes among the isolated pneumococcal strains from sputum before and after vaccination were studied. Results: The number of the isolated strains was as follows: prior to the vaccination, 24 isolates in the vaccinated group, 18 isolates in the non-vaccinated group; after vaccination (within 5 years), 53 isolates in the vaccinated group, 46 isolated in the non-vaccinated group. The PV decreased the frequency of Penicillin G-resistant strains successfully (from 16.7 to 7.5%) in the vaccinated group while the frequency increased (from 5.5 to 15.2%) in the non-vaccinated group during the same period. In genetic analysis, the rates of strains with altered pbp1a, pbp2x and pbp2b were decreased in the vaccinated group than the non-vaccinated group (28.6% versus 53.3%). Conclusions: The 23-valent pneumococcal polysaccharide vaccine may have a preventive effect against drug-resistant Streptococcus pneumoniae.
KEYWORDS: The 23-valent pneumococcal polysaccharide vaccine, Penicillin resistant Streptococcus pneumoniae, Drug resistant Streptococcus pneumoniae, Penicillin binding protein
RECEIVED: 2009.3.10
JJRS, 47(12): 1063-1069, 2009
