The Journal of the Japanese Respiratory Society ONLINE JOURNAL
ABSTRACT
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Article in Japanese
Case Report
A case of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome, complicated with disseminated M. abscessus infection
Yukari Asai1)2), Hiroshi Ouchi1), Tukasa Ohosima1), Ryuji Nakano1), Yujiro Yamano1), Ichiro Inoshima2), Takuji Yamauchi2), Satoshi Fukuyama2), Hiromasa Inoue2) and Yoichi Nakanishi2)
1)Kyushu Kousei Nenkin Hospital
2)Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
ABSTRACT
A 27-year-old man was admitted to our hospital complaining of a persistent high fever since August 2007. Chest radiography showed infiltration shadows in the right lower lung field. Chest CT revealed scattered small nodular shadows and patchy consolidations in the right lower lobe. He was diagnosed as secondary pulmonary alveolar proteinosis (sPAP) associated with myelodysplastic syndrome (MDS), confirmed by video-assisted thoracic surgery (VATS) and bone marrow aspiration. Sera were negative for anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. He developed a subcutaneous abscess and meningitis caused by M. absessus after VATS. After a long-course of antibiotic therapy, an allogenic peripheral blood stem cell transplantation was performed. But he died of graft versus host disease and M. abscessus sepsis 87 days after transplantation.
KEYWORDS: Secondry pulmonary alveolar proteinosis, Myelodysplastic syndrome, Mycobacterium abscessus, Steroid drug, Peripheral Blood Stem Cell Transplantation
RECEIVED: 2009.4.13
JJRS, 47(12): 1120-1125, 2009
