The Journal of the Japanese Respiratory Society ONLINE JOURNAL
ABSTRACT
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Article in Japanese
Case Report
A case of rapidly growing inflammatory myofibroblastic tumor in the lung
Saiko Suetsugu1), Hidetaka Yamamoto2), Miiru Izumi1), Koichi Takayama1), Hiromasa Inoue1) and Yoichi Nakanishi1)
1)Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
2)Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University
ABSTRACT
We report a case of a 28-year-old man with a dry cough and chest pain. Chest X-ray film showed a huge mass in the right lung field. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a huge mass which occupied most of the right thoracic cavity and invaded the superior vena cava, heart atrium and right pulmonary vein. Positron emission tomography (PET) showed metastasis of bone, right adrenal grand and lymph nodes. A tumor specimen was biopsied percutaneously, and the diagnosis was pathologically confirmed as an inflammatory myofibroblastic tumor. Immunohistochemical staining also showed an overexpression of ALK in the tumor. He was treated with a non-steroid anti-inflammation drug and steroid, but they were ineffective. He underwent chemotherapy with bleomicin, etoposide and cisplatin. After two cycles of chemotherapy, the tumor slightly reduced in size, but was eventually refractory to the regimen finally. He also underwent with paclitaxel and carboplatin. At present, if operative extirpation is not possible, there is no way to treat an inflammatory myofibroblastic tumor. In the future, new therapy incorporating ALK inhibitors would be expected to treat those cases of IMT in which local recurrences and distant metastases occur.
KEYWORDS: Inflammatory myofibroblastic tumor, ALK, Chemotherapy
RECEIVED: 2009.5.21
JJRS, 47(12): 1156-1160, 2009
