The Journal of the Japanese Respiratory Society ONLINE JOURNAL
ABSTRACT
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Article in Japanese
Case Report
A case of IgG4-positive inflammatory pseudotumor which rapidly resolved
Kentaro Sakashita1), Mikio Takamori1), Kengo Murata1), Akihiko Wada1), Akira Fujita1) and Kazuaki Enatsu2)
1)Department of Respiratory Medicine, Tokyo Metropolitan Tama Medical Center
2)Department of Pathology, Tokyo Metropolitan Tama Medical Center
ABSTRACT
A 72-year-old man visited our hospital due to persistent cough, fever and weight loss. A chest X-ray film revealed a round tumor in the left lower lung field. A specimen obtained by transbronchial lung biopsy demonstrated histiocytic and lymphocytic infiltration in the alveolar space, with spindle myofibroblasts and plasmacytes in the interstitium, Those findings were consistent with inflammatory pseudotumor. Four weeks later, a chest X-ray film showed only scars of the primary lesion, and his symptoms resolved dramatically. He has had no recurrence of symptoms and pulmonary tumor since then. Although spontaneous remission is uncommon in inflammatory pseudotumor of the lung, there are several case reports about spontaneous remission of hepatic inflammatory pseudotumor and autoimmune pancreatitis, parts of IgG4-related screlosing disease. Recently, inflammatory pseudotumor is thought to be IgG4-related screlosing disease. We speculate that IgG4 may be associated with spontaneous remission of inflammatory pseudotumor of the lung, and we discuss this issue in relation to the pertinent literature.
KEYWORDS: Inflammatory pseudotumor of the lung, IgG4-related sclerosing disease, Regression of the tumor
RECEIVED: 2010.2.3
JJRS, 49(3): 172-177, 2011
