The Journal of the Japanese Respiratory Society ONLINE JOURNAL
ABSTRACT
Full Text of PDF (168k)
Article in Japanese
Original Article
A Focal Usual Interstitial Pneumonia Lesion: An Important Risk Factor in Diffuse Alveolar Damage-Acute Exacerbation of a Focal Usual Interstitial Pneumonia Patient-
Yoshinori Kawabata1) , Kazuo Fukushima2) , Takashi Uchiyama3) , Hironobu Sugita3) and Bunpei Kimura4)
1)Department of Laboratory Medicine, Saitama Cardiovascular Respiratory Center, 2)Department of Internal Medicine, National Sanatorium Saishunsou Hospital, 3)Department of Respiratory Medicine, Double Red Cross Hospital, 4)Department of Thoracic Surgery, Tokyo Kensei Hospital, 1696, Itai Konan, Ohsato, Saitama 360-0105
ABSTRACT
The aim of this study was to clarify whether the presence of a focal usual interstitial pneumonia lesion (F-UIP) is a risk factor for diffuse alveolar damage (DAD). Our subjects were 977 patients (681 males, 296 females, mean age, 64years). The incidence of F-UIP increased significantly with age (between 50 and 60 years, 3% and8%, p<0.05; between60and 70 years, 8% and14.1%, p<0.05; and between 70 and 80 years, 14.1% and 27.9%, p<0.01). The mean age of the non-UIP group was 64 years, and of the F-UIP group was 75 years, showing significance (p<0.001). The incidence of DAD was higher in the F-UIP group (100 patients, 30%, p<0.01) and the diffuse UIP group (60 patients, 30%, p<0.01) than in the non-UIP group (817 patients, 5.3%). Although the causes of DAD were various, the presence of F-UIP was a important risk factor of DAD.
KEYWORDS: Focal UIP lesion, Idiopathic UIP, Diffuse alveolar damage, Acute exacerbation
RECEIVED: 2000.4.17
JJRS, 39(5): 316-321, 2001
