The Journal of the Japanese Respiratory Society ONLINE JOURNAL

 ONLINE JOURNAL TOP   VOL.39 NO.5 TABLE OF CONTENTS

JAPANESE/ENGLISH

ABSTRACT

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Article in Japanese

A 73-year-old man was referred to our department because of sputum production and fever. He had undergone a total laryngectomy for laryngeal cancer. His chest radiograph showed patchy ground-glass shadows in both lung fields. He was treated with antibiotics for pneumonia, but his symptoms continued, and the size of the patchy shadows in the chest radiograph increased. Inhalation therapy with ElaseR had been started from one day before fever arose. Withdrawal of ElaseR treatment resolved his symptoms. We therefore suspected drug-induced interstitial pneumonia. Transbronchial lung biopsy specimens showed infiltration of lymphocytes in the alveolar septa and thickening of those septa. A bronchoalveolar lavage revealed an increased number of lymphocytes, and the CD4/CD8 ratio was 0.3. A drug lymphocyte stimulation test (DLST) with peripheral blood lymphocytes was strongly positive (S.I.2127%) for ElaseR. The anti-nuclear antigen (ANA) was detected (× 640), and the anti-single strand DNA antibody titer was also high (123.4IU/ml). About10weeks after the withdrawal of ElaseR, the infiltrative shadows and the abnormal laboratory findings improved spontaneously. On the basis of these findings, we arrived at a diagnosis of drug-induced interstitial pneumonia associated with inhalation of ElaseR.

KEYWORDS: Elase^®, Drug induced interstitial pneumonia, Drug lymphocyte stimulation test, Antinuclear antigen

RECEIVED: 2000.8.7

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