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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Clostridioides difficile infection in Japan: Molecular epidemiology |
| Language |
J |
| AuthorList |
Haru Kato, Mitsutoshi Senoh |
| Affiliation |
Department of Bacteriology II, National Institute of Infectious Diseases |
| Publication |
J.J.C.M.: 31 (2), 66-74, 2021 |
| Received |
February 16, 2021 |
| Accepted |
|
| Abstract |
We overview the molecular epidemiology of Clostridioides difficile infection (CDI) in Japan by reviewing articles including outbreak reports and case reports, in which typing analysis was performed on recovered C. difficile isolates. The most common PCR-ribotype (RT) associated with CDI in Japan was RT018-related type, including RT018, RT018' RT018", and RT052, which has not significantly changed during the 20 years from the late 1990s. In most studies, RT018-related type, RT014, RT002, RT369, RT017, and RT001 accounted for more than 70%. In addition, RT018-related type, RT369, and RT002 have been reported to cause outbreaks in Japanese hospitals. Isolation rate of binary toxin (CDT)-positive strains was low (2-6%), except in one study (11%). While there was a report of a nosocomial outbreak due to RT027 C. difficile in 2019, isolation of RT027 as well as RT078 was rare in endemic settings. Infections by CDT-positive C. difficile such as RT027 in Japan, may have different features from those in North America and Europe. Comprehensive surveillance for CDI has not been implemented in Japan, resulting the low awareness and understanding of CDI not only in healthcare settings but also in administrative settings. In order to understand the CDI burden in Japan, a nationwide strain-based surveillance system is needed. |
| Keywords |
PCR-ribotype (RT) |
|
