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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
MIC measurement kit for rapidly growing mycobacteria multicenter evaluation |
| Language |
J |
| AuthorList |
Akio Aono1), Kinuyo Chikamatsu1), Yuriko Igarashi1), Shimomura Yoshiko1), Makiko Hosoya1), Yuta Morishige1), Yoshiro Murase1), Akiko Takaki1), Hiroyuki Yamada1), Satoshi Mitarai1,2) |
| Affiliation |
1) Bacteriology Division, Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
2) Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences |
| Publication |
J.J.C.M.: 31 (2), 75-81, 2021 |
| Received |
July 7, 2020 |
| Accepted |
November 4, 2020 |
| Abstract |
In September 2019, Kyokuto Pharmaceutical Industry Co., Ltd. released a MIC measurement kit for rapidly growing mycobacteria (RGM) corresponding to CLSI M24 3rd ed. Prior to this event, we conducted a multicenter evaluation study to see the clinical feasibility of the kit for MIC measurement of RGM. A total of 23 laboratories participated the study voluntarily and results were obtained from them all. The operation was performed according to the standard of CLSI M24 3rd ed. The overall concordance by type of drug was 73.9% to 98.3%, and the reproducibility of MIC was ≥ 95%, which was observed in 75% of the laboratories. On the other hand, some facilities reported MICs out of range in results, and it seemed necessary to carry out appropriate and continuous training before and after introduction of the kit. |
| Keywords |
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