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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Desulfovibrio Bacteremia: A Report of Eight Cases |
| Language |
J |
| AuthorList |
Yoko Ida1), Koji Araki1), Shota Yonetani2), Takahiro Okuyama1), Megumi Takagi1), Chihiro Hirao1), Shintaro Honma1), Wataru Ogura1), Mio Suzuki1), Ayaka Ito1), Ayaka Horiguchi1), Kumiko Sekiguchi1), Hiroaki Ohnishi1,3) |
| Affiliation |
1) Department of Clinical Laboratory, Kyorin University Hospital
2) Department of Medical Technology, Faculty of Health Science, Kyorin University
3) Department of Laboratory Medicine, Faculty of Medicine, Kyorin University |
| Publication |
J.J.C.M.: 32 (1), 38-43, 2022 |
| Received |
June 9, 2021 |
| Accepted |
October 13, 2021 |
| Abstract |
Desulfovibrio spp. rarely cause bacteremia and liver abscesses, but there are a few published reports. In this study, we reviewed the patient background, species identification, and susceptibility testing of 8 cases of bacteremia caused by Desulfovibrio spp. treated in our hospital between 2012 and 2020. Two cases of "Desulfovibrio fairfieldensis" and six cases of Desulfovibrio desulfuricans MB were isolated from blood cultures during the culture period of 2-5 days. Most of the cases presented with transient bacteremia in patients with concomitant gastrointestinal disease, and the prognosis of the patients was excellent except for a fatal case due to comorbidity. For bacterial species identification testing, 16S rRNA gene analysis was the most useful, and analysis by identification kits or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was unsuccessful for all strains. However, after we registered isolates of case 1 ("D. fairfieldensis") and case 3 (D. desulfuricans MB) in MALDI-TOF MS library, we could successfully detect correct Desulfovibrio species for all re-examined cases. For susceptibility testing, difference in drug susceptibility to beta-lactams was observed between the two species, suggesting the importance of species identification. In addition, some strains showed higher MIC values of fluoroquinolones than others, indicating the importance of strain-specific drug susceptibility testing. All the strains showed good antibacterial activity against clindamycin and metronidazole. The present study suggest that the 2 species should be incorporated into the library of mass spectrometry and that drug susceptibility should be standardized for better treatment of bacteremia by these species. |
| Keywords |
MALDI-TOF MS |
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