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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
A case of central venous port-related bloodstream infection caused by Wickerhamomyces anomalus |
| Language |
J |
| AuthorList |
Masahiro Ikedo, Toru Kago |
| Affiliation |
Department of Central Clinical Laboratory, Meitetsu Hospital |
| Publication |
J.J.C.M.: 32 (2), 103-110, 2022 |
| Received |
September 29, 2021 |
| Accepted |
December 1, 2021 |
| Abstract |
We report a central venous (CV) port-related bloodstream infection caused by Wickerhamomyces anomalus, a rare yeast-like fungus formerly known as Pichia anomala, in a male patient in his 80s. The patient was hospitalized when he did not recover from fever and dysuria for 6 days. On the third day after hospitalization, we detected yeast-like fungi in his blood sample collected at the time of visit. The same yeast-like fungi were detected in a sample from the CV port, collected on the eighth day after hospitalization, on the right side of the patient's chest. Using a fungus identification panel (RYID; Beckman Coulter), we initially identified the fungus as P. anomala. However, P. anomala is a yeast-like fungus whose detection frequency is low. No characteristically shaped ascospores formed in the sexual generation required to determine P. anomala could be observed either. Therefore, it was difficult to make a conclusion with RYID analysis alone. The identity of the fungus in the patient was reanalyzed by mass spectrometry (MALDI-Biotyper) and determined to be W. anomalus. As the colony characteristics of W. anomalus on CHROMagar Candida are similar to those of Candida parapsilosis, it is difficult to identify the former using this differential medium. We therefore compared the growth and morphology of W. anomalus and Candida spp. on BTB lactose agar medium. W. anomalus formed small moss-green colonies on BTB lactose agar, confirming a clear developmental difference from Candida spp. Our findings may provide a novel means of distinguishing W. anomalus from Candida spp. |
| Keywords |
Wickerhamomyces anomalus |
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