 |
 |
 |
The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
|
[Vol.32 No.4 contents] Japanese / English |
|
| ArticleTitle | Growth characteristics of C. glabrata and non-C. glabrata in blood culture bottles in patients with candidemia |
| Language | J |
| AuthorList | Yuji Teshima1), Takashi Matono2), Yoshimi Furuno1), Hidenobu Koga3), Rie Akinaga1) |
| Affiliation |
1) Department of Clinical Laboratory, Aso Iizuka Hospital 2) Department of Infection Diseases, Aso Iizuka Hospital 3) Department of Clinical Research Support Office, Aso Iizuka Hospital |
| Publication | J.J.C.M.: 32 (4), 234-237, 2022 |
| Received | March 25, 2022 |
| Accepted | May 31, 2022 |
| Abstract |
In patients with candidemia, Candida glabrata takes longer than other Candida species to reach the positivity cut-off value in blood culture bottles; it can also grow in anaerobic bottles. We retrospectively assessed the growth characteristics of Candida species in blood culture bottles. We analyzed 76 Candida strains (36 C. glabrata and 40 non-C. glabrata) in blood cultures using BACTEC FX from January 2014 to October 2018. Positivity was more frequently observed in anaerobic bottles with C. glabrata than in those with non-C. glabrata (41.7% vs.0.0%; p < 0.001). Furthermore, among the 11 cases of C. glabrata detected in anaerobic and aerobic bottles, 81.8% grew earlier in anaerobic bottles than in aerobic bottles. Time to positivity (TTP) was more prolonged in C. glabrata (median 47.0 hours) than those in non-C. glabrata (median 35.6 hours; p = 0.035). The area under the curve (AUC) of TTP for predicting C. glabrata was 0.64 (95% CI: 0.52-0.77). These findings suggest that C. glabrata is easy to grow in anaerobic bottles using BACTEC FX. The growth characteristics of Candida species in blood culture bottles may be beneficial in the prediction of C. glabrata, aiding the clinical selection of appropriate antifungal agents. |
| Keywords | Candida glabrata, BACTEC FX |
| Copyright © 2002 The Japanese Society for Clinical Microbiology All rights reserved. |