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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
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[Vol.33 No.1 contents] Japanese / English |
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| ArticleTitle | Clinical Efficacy of a Filmarray Device In A Hospital Specializing In Acute Geriatric Care |
| Language | J |
| AuthorList | Yutaka Noguchi1,5), Masaki Takigawa2,5), Ryoko Asami1,5), Tomoko Furukawa1,5), Tomoya Obara2,5), Yohei Maeda2,5), Mamoru Sato2,5), Yoshitomo Shimazaki2,5), Nami Dezaki3,5), Hiroshi Koganemaru4,5), Yoshishige Masuda1,5) |
| Affiliation |
1) Division of Laboratory Medicine, Tokyo Metropolitan Geriatric Hospital 2) Department of Pharmacy, Tokyo Metropolitan Geriatric Hospital 3) Department of Nursing, Tokyo Metropolitan Geriatric Hospital 4) Infectious Diseases, Tokyo Metropolitan Geriatric Hospital 5) Infection Control Team, Tokyo Metropolitan Geriatric Hospital |
| Publication | J.J.C.M.: 33 (1), 44-51, 2022 |
| Received | July 5, 2022 |
| Accepted | October 5, 2022 |
| Abstract | FilmArray (FA) may contribute to the treatment of bloodstream infections; however, there are no reports regarding its utility in Japan. Hence, we aimed to investigate the clinical efficacy of FA at our hospital, which specializes in acute geriatric care. To determine clinical efficacy, we compared the background of bacteremia cases associated with Staphylococcus spp. and Candida spp. in two terms between November 2019 and April 2020. The first and second terms represent the time duration before and after the introduction of FA, respectively. Interim reporting time was significantly shorter in Staphylococcus-positive cases in the first term (39.2 hours) than in the second term (11.1 hours, p<0.001). There was a trend toward shortening between Candida-positive cases in the first and second terms (83.5 hours vs. 13.9 hours). The time to de-escalation tended to be shorter in Staphylococcus-positive and Candida-positive cases, respectively. There was no significant difference in the in-hospital mortality rate and the 30-day mortality rate between the first and the second term. Antimicrobial use density (AUD) and days of therapy (DOT) for vancomycin decreased in the second term compared to those in the first term. The results showed that FA introduction resulted in shorter interim reporting time, lesser days for de-escalation, and decreased AUD and DOT for vancomycin. Conversely, there was no improvement in the 30-day mortality rate. Thus, the results suggest that FA introduction may contribute to the appropriate use of antimicrobial agents. However, further studies are needed to improve the 30-day mortality rate. |
| Keywords | FilmArray, Staphylococcus aureus, Candida spp. |
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