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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
A case of bacteremia due to oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA) |
| Language |
J |
| AuthorList |
Yu Suzuki1), Daisuke Akaneya1), Yuka Yamaguchi1), Shintaro Nemoto2), Shuichi Abe3) |
| Affiliation |
1) Department of Clinical Laboratory, Yamagata Prefectural Central Hospital
2) Department of Orthopedics, Yamagata Prefectural Central Hospital
3) Department of Infectious Disease, Yamagata Prefectural Central Hospital |
| Publication |
J.J.C.M.: 33 (1), 64-68, 2022 |
| Received |
July 12, 2022 |
| Accepted |
September 30, 2022 |
| Abstract |
Here we report a case of oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA) bacteremia. A patient was 89-year-old woman who had undergone spinal fusion 10 years ago, and admitted to hospital due to subcutaneous abscess at surgical site. Gram positive cocci with clustered form were observed in smear of the abscess, thus she was administrated daptomycin considering the possibility of infection with methicillin-resistant S. aureus (MRSA). S. aureus was isolated from blood culture sample and mecA detection assay revealed that the strain possessed mecA. However, antimicrobial susceptibility testing revealed that the strain was methicillin- susceptible S. aureus (MSSA) phenotypically as it was susceptible to oxacillin. Therefore, this case was considered as OS-MRSA bacteremia. The patient was kept to be administrated daptomycin and her fever resolved 5 days after the administration. It is known that MRSA could be induced by exposure to oxacillin or cefoxitin from OS-MRSA strain. Furthermore, Clinical and Laboratory Standards Institute recommends reporting OS-MRSA as MRSA to clinician. Hence, administration of anti-MRSA drug should be considered for OS-MRSA infection case. It should be required for proper detection of OS-MRSA to confirm no contamination of any other mecA-positive bacteria, such as mecA-positive coagulase-negative Staphylococci. PBS2a detection test or MRSA screening culture media would be useful for the detection of OS-MRSA. |
| Keywords |
Staphylococcus aureus, OS-MRSA, mecA |
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