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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
MIC measurement kit for Slow Growing mycobacteria multicenter evaluation |
| Language |
J |
| AuthorList |
Akio Aono1), Kinuyo Chikamatsu1), Yuriko Igarashi1), Manabu Inoue2), Maki Kitagawa2), Yoshiko Shimomura1), Makiko Hosoya1), Yuta Morishige1), Yoshiro Murase1), Akiko Takaki1), Satoshi Mitarai1,3) |
| Affiliation |
1) Bacteriology division, Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
2) Product Development Division KYOKUTO PHARMACEUTICAL INDUSTRIAL CO., LTD.
3) Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences |
| Publication |
J.J.C.M.: 34 (1), 18-24, 2023 |
| Received |
May 25, 2023 |
| Accepted |
September 27, 2023 |
| Abstract |
In March 2023, Kyokuto Pharmaceutical Industries, Ltd. released a MIC assay kit for slow-growing non-tuberculosis Mycobacteria (SGM) in compliance with CLSI M24 3rd ed. Prior to this, we conducted a multicenter study to evaluate the clinical feasibility of the kit for MIC measurement of SGM. The MIC assay was performed according to the criteria of CLSI M24 3rd ed. The overall concordance rate by agent was 69.1% to 98.9%, and the reproducibility of MICs was good, with 68.6% (95% CI: 57.7-79.4) of each drug showing reproducibility of 90.0% or higher, suggesting that the kit is suitable for use in clinical bacteriological testing. On the other hand, some laboratories reported results that deviated from the reference values, which commonly occurs in MIC measurement, then appropriate and continuous training before and after the introduction of the kit is considered necessary. |
| Keywords |
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