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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Analysis of bacterial isolates and laboratory findings in cerebrospinal fluid at Nagasaki University Hospital in the past 10 years |
| Language |
J |
| AuthorList |
Hina Kodama1), Yasuhide Kawamoto1), Norihiko Akamatsu1), Yumiko Kimura1), Kosuke Kosai2), Katsunori Yanagihara1,2) |
| Affiliation |
1) Department of Laboratory Medicine, Nagasaki University Hospital
2) Department of Laboratory Medicine, Nagasaki University, Graduate School of Biomedical Sciences |
| Publication |
J.J.C.M.: 34 (4), 273-278, 2024 |
| Received |
February 20, 2024 |
| Accepted |
June 24, 2024 |
| Abstract |
We investigated the annual trend in the number of cerebrospinal fluid (CSF) samples obtained by puncture and their laboratory findings, including biochemical test, direct smear, and culture, during the 10-year period from 2012 to 2021 in Nagasaki University Hospital. The number of samples tended to slightly decrease from 2013 to 2017 and remained unchanged thereafter. The average positive rate of culture was 6.6%. In the comparisons between the groups of samples from whose causative pathogens and contaminants were isolated, the levels of CRP in blood and CSF protein and the rate of polymorphonuclear leukocytes in CSF were higher and the level of CSF glucose was lower in the former group. The positive rates were 26.0% (40/154) for conventional culture and 74.0% (114/154) for enrichment culture only. Staphylococcus aureus was the most common organism isolated in conventional culture. In enrichment culture, more than half (65.0%, 74/114) of isolates were presumed to be contaminants, such as CNS and Cutibacterium acnes; however, several bacteria, such as Moraxella sp. and anaerobes, were isolated from only enrichment culture, suggesting that enrichment culture can effectively detect these pathogens. |
| Keywords |
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