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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Issues identified through epidemiological studies of invasive GBS diseases in children |
| Language |
J |
| AuthorList |
Naruhiko Ishiwada, Noriko Takeuchi, Misako Ohkusu |
| Affiliation |
Department of Infectious Diseases, Medical Mycology Research Center, Chiba University |
| Publication |
J.J.C.M.: 35 (2), 132-137, 2025 |
| Received |
October 25, 2024 |
| Accepted |
|
| Abstract |
Based on the results of the clinical and bacteriological study of invasive group B streptococcus (GBS) diseases in children conducted in Chiba Prefecture for over 10 years, we discussed the optimizing strategy for prevention of neonatal invasive GBS diseases. The incidence of pediatric invasive GBS diseases is now higher than that of pediatric invasive Haemophilus influenzae diseases and invasive pneumococcal diseases after the introduction of Haemophilus influenzae type b vaccine and pneumococcal conjugate vaccine era in Japan. Regarding prognosis, approximately 25% of children with invasive GBS diseases have neurological sequelae or death. Although the administration of antibiotics during delivery to GBS-positive pregnant women to prevent invasive GBS diseases in newborns has been shown to be effective in preventing early-onset GBS diseases, it is difficult to prevent all invasive GBS diseases, and it is necessary to introduce a standardized maternal GBS screening test method. In addition, vaccination of pregnant women to prevent late-onset GBS infections should be considered in the future, and it is important to conduct serotype analysis of GBS clinical isolates. It is also necessary to perform drug susceptibility monitoring, including resistance gene analysis of GBS clinical isolates, and present optimal antibiotic treatment guidelines for invasive GBS diseases in children. |
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