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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Ten-year temporal trends in the minimum inhibitory concentration of Candida species isolated from blood cultures |
| Language |
J |
| AuthorList |
Yoshiki Kusama1,2,4), Hiroo Matsuo1,2,4), Atsuko Sunada3), Go Yamamoto2,4), Satoshi Kutsuna1,2,4) |
| Affiliation |
1) Department of Infectious Disease, University of Osaka Hospital
2) Department of Infection Control and Prevention, University of Osaka Hospital
3) Department of Clinical Laboratory, University of Osaka Hospital
4) Center for Infectious Disease Education and Research (CiDER) |
| Publication |
J.J.C.M.: 35 (2), 157-161, 2025 |
| Received |
August 16, 2024 |
| Accepted |
December 23, 2024 |
| Abstract |
Candida species are the most frequently isolated fungi in invasive fungal infections, and their antifungal resistance has recently increased. Here, we observed trends in the minimum inhibitory concentrations (MICs) of Candida spp. isolated from the bloodstream for 10 years at a university hospital in Japan. This study used Candida spp. isolated from blood cultures collected between January 2014 and December 2023. We evaluated the annual changes in the isolation rate of Candida spp. from the number of patients submitted blood culture, detected species, and MICs of fluconazole, voriconazole, micafungin, and caspofungin against Candida albicans, Candida parapsilosis, and Candida glabrata. The isolation rate of Candida spp. from blood cultures significantly increased during the study period (P < 0.01). As the number of blood cultures increases, a significant correlation was observed between the number of patients submitted blood culture and the isolation rate of Candida spp. (Spearman's rank correlation coefficient 0.669, P = 0.035). No significant changes were observed in the proportions of C. albicans, C. parapsilosis, and C. glabrata. The MICs for fluconazole (P = 0.01) and voriconazole (P < 0.01) against C. parapsilosis significantly increased during the study period. The increase in MICs occurred within the "susceptible" breakpoint range and may have been unnoticed in susceptibility surveillance. This suggests that observing MIC fluctuations in Candida spp. across multiple facilities is necessary. |
| Keywords |
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