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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Drug-resistant Acinetobacter baumannii～An overview of methods for detecting their carbapenemase production～ |
| Language |
J |
| AuthorList |
Kohei Uechi1,2), Teruo Kirikae3,4), Jiro Fujita2), Shiro Maeda1) |
| Affiliation |
1) Division of Clinical Laboratory and Blood Transfusion, University Hospital of the Ryukyus, Okinawa, Japan
2) Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
3) Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan
4) Department of Infectious Disease, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan |
| Publication |
J.J.C.M.: 28 (2), 83-97, 2018 |
| Received |
January 20, 2018 |
| Accepted |
|
| Abstract |
The emergence and dissemination of drug-resistant Gram-negative bacilli, i.e. carbapenem-resistance, have been recognized as a serious health concern worldwide. Acinetobacter baumannii, a known nosocomial pathogen isolated in hospitals, is particularly important showing the highest incidence rate of isolation among Acinetobacter species and the propensity to acquire early antibiotic resistance. Many outbreaks of multidrug-resistant Acinetobacter species (MDRA) and the spread of OXA-23-like carbapenemase producing Acinetobacter species have been reported worldwide, with outbreaks of MDRA also reported sporadically in Japan. According to Japanese Nosocomial Infections Surveillance (JANIS) 2016, the susceptibility of Acinetobacter species to carbapenem and other antimicrobial drugs is relatively good, but it is necessary to make close attention for the dissemination of MDRA in Japan. The main mechanism of carbapenem-resistance in A. baumannii is explained by a production of carbapenem hydrolyzing class D β-lactamase (CHDL), including OXA-51-like, OXA-23-like and OXA-58-like CHDL. It is acknowledged that current phenotypic tests for carbapenemase-production of Acinetobacter species have sensitivity and specificity shortfalls. An accurate detection method is required to avoid the spread of this pathogen in the future. In this review, we focus on A. baumannii to discuss the current situation of drug-resistance and detection methods in carbapenemase-producing Acinetobacter species. |
| Keywords |
Acinetobacter baumannii, modified Hodge Test（MHT）, CarbaNP test, Carbapenem Inactivation Method（CIM） |
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