 |
The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Comparing the susceptibility results between RSMY1 and FP 'EIKEN' using Candida isolates |
| Language |
J |
| AuthorList |
Ito Kato1), Masayoshi Osaka2), Tomoaki Sato1), Kenji Iwawaki2), Yusuke Nomura1), Shu Okukawa1), Kyoji Moriya1) |
| Affiliation |
1) Department of infection control, and Prevention The University of Tokyo Hospital
2) Nissui Pharmacentical CO., LTD. |
| Publication |
J.J.C.M.: 28 (2), 119-125, 2018 |
| Received |
July 6, 2017 |
| Accepted |
December 15, 2017 |
| Abstract |
We evaluated the utility of RAISUS susceptibility testing plates of yeasts (RSMY1), an automated susceptibility testing method, by using Candida isolates from blood cultures and intravascular catheters. For comparison we measured the same strains with Yeast-Like Fungus DP (FP 'EIKEN'). Micafungin (MCFG), Amphotericin-B (AMPH-B), Flucytosine (5-FC), Fluconazole (FLCZ), Itraconazole (ITCZ), Voriconazole (VRCZ) and Miconazole (MCZ) were tested with 53 Candida isolates from clinical samples and Clinical and Laboratory Standards Institute (CLSI) quality control strains. The MIC values of quality control strains obtained from both methods were acceptable ranges of the CLSI standards (M27-S3). The MIC values of all antifungal agents showed high correlation rate between two methods. In MIC comparison, essential agreements between two methods (±fourfold of MICs) were over 90%with exception of MCFG (77%) and MCZ (86%). The categorical agreement between two methods was over 90% for antifungal agents with exception of ITCZ. ITCZ had 17% very major error. There was a 31%, 2% and 8% minor error for ITCZ, VRCZ and FLCZ, respectively.
The understanding differences and features of methods are important when the antifungal susceptibility testing in clinical laboratory is performed. |
| Keywords |
Candida |
|
