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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Molecular mechanisms involved in acquiring antibiotic resistance in pathogenic Gram-negative bacteria |
| Language |
J |
| AuthorList |
Jun-ichi Wachino |
| Affiliation |
Department of Bacteriology, Nagoya University Graduate School of Medicine |
| Publication |
J.J.C.M.: 30 (1), 1-12, 2019 |
| Received |
November 5, 2019 |
| Accepted |
|
| Abstract |
The emergence of various antibiotic resistant bacteria is a major clinical concern. Bacterial antibiotic resistance is classified into intrinsic (e.g., amino acid substitutions in DNA gyrase conferring quinolone resistance) and acquired (e.g., acquisition of metallo-β-lactamase genes involved in carbapenem resistance). Acquired antibiotic resistance genes are mediated by mobile genetic elements in bacteria, such as plasmids. The transfer of plasmids via conjugation is a primary cause for the spread of antibiotic resistance genes within bacterial species. Transformation and transduction via phages also contribute to spreading antibiotic resistance. Moreover, integrons and transposons are involved in accumulating and transposing antibiotic resistance genes in bacteria, respectively. This review discusses the molecular mechanisms involved in the acquisition and spread of antibiotic resistance genes in clinically-relevant antibiotic-resistant Gram-negative bacteria. |
| Keywords |
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