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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Two cases with severe complications caused by Clostridioides difficile PCR-ribotype 002 and an outbreak at the ward where they were hospitalized |
| Language |
J |
| AuthorList |
Nana Furukawa1), Kumiko Oota1), Mitsutoshi Senoh2), Haru Kato2) |
| Affiliation |
1) Department of Clinical Laboratory, Hiratsuka Kyosai Hospital
2) Department of Bacteriology II, National Institute of Infectious diseases |
| Publication |
J.J.C.M.: 30 (2), 74-79, 2020 |
| Received |
October 8, 2019 |
| Accepted |
January 21, 2020 |
| Abstract |
Clostridioides difficile infection (CDI) can develop into a serious disease. CDI is one of the most common hospital-acquired infection. Two patients were given the diagnosis of CDI with severe complications on the same day at the same ward. Patient-1 suffered from toxic megacolon and died. Patient-2 had shock with bacteremia due to C. difficile but survived. At the ward where the two patients were admitted, nine new cases CDI including the two cases were identified for 20 days, suggesting an acute outbreak. C. difficile isolates from stool specimens of patient-1 and patient-2, and from blood of patient-2 were examined. In addition, three isolates from other three patients, who suffered from CDI during the outbreak, were available for analysis. All six isolates examined were toxin A-positive, toxin B-positive, binary toxin-negative and identified as PCR-ribotype 002. PCR-ribotype 002 C. difficile may be noted not only for its virulence on disease severity but as a successful epidemic genotype. |
| Keywords |
PCR-ribotype 002 |
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