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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Serotype and drug susceptibility of Streptococcus pneumoniae isolated from pediatric acute otitis media after 13-valent pneumococcal conjugate vaccine introduction |
| Language |
J |
| AuthorList |
Katsunori Takashima1), Junko Masaki1), Daiki Ozawa2) |
| Affiliation |
1) Department of Central Clinical Laboratory, Tohoku Rosai Hospital, Organization of Occupational Health and Safety
2) Department of Otolaryngology-Head and Neck Surgery, Tohoku University |
| Publication |
J.J.C.M.: 31 (1), 11-16, 2020 |
| Received |
September 1, 2020 |
| Accepted |
October 14, 2020 |
| Abstract |
Streptococcus pneumoniae is one of the predominant bacteria that causes acute otitis media (AOM). The 13-valent pneumococcal conjugate vaccine (PCV13) has been included in the routine immunization schedule in Japan since November 2013. After vaccine introduction, non-vaccine types increased due to serotype replacement. We surveyed the serotypes and antimicrobial susceptibility profile of 44 S. pneumoniae isolates obtained from the middle ear fluid of children with AOM from March 2017 to February 2018. Only 38.6% of the strains were susceptible to penicillin G, while 40.9% were penicillin-intermediate strains, and 20.5% were penicillin-resistant strains. The most prevalent serotypes found were serotype 15A (15.9%), and serotype 23B (11.4%). PCV7 types accounted for 0% of all strains, while 9.1% were PCV13 types. Serotype 15A strains were 100% non-susceptible to penicillin G, and all were in under 2-year-olds. Serotype 15A and 23B are not included in the PCV13, suggesting serotype replacement may have occurred. Serotype 15A should be noted as a cause of intractable AOM in under 2-year-olds. Finally, the high prevalence of non-susceptible serotype 15A highlights the need for further monitoring of serotype 15A trends. |
| Keywords |
Streptococcus pneumoniae, PCV13, serotype |
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