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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Mupirocin susceptibility of Staphylococcus aureus strains isolated from nasal specimens |
| Language |
J |
| AuthorList |
Yasuhiro Shibuya1,3), Harumi Koibuchi1), Takashi Ohno2), Kouichi Itoh1) |
| Affiliation |
1) Department of Clinical Laboratory Medicine and
2) Clinical Laboratory, Jichi Medical School
3) Present address for corresponding; Department of Respiratory Medicine, Tokyo Metropolitan Hiroo General Hospital |
| Publication |
J.J.C.M.: 13 (1), 15-18, 2003 |
| Received |
November 12, 2002 |
| Accepted |
March 3, 2003 |
| Abstract |
The mupirocin (MUP) and oxacillin (MPIPC) susceptibility of 315 Staphylococcus aureus strains isolated from nasal specimens was evaluated. Clinically isolated strains obtained at a Japanese teaching hospital between October 2000 and March 2002 were used in this study. Minimal inhibitory concentration (MIC) was assayed by E test. MIC values of MUP were distributed between < 0.064 and 4 μ /ml. A total of 6 strains (1.9%) showed low-level resistance (MIC=4-256 μ /ml), while no strains showed high-level resistance. MUP-resistant strains included 0.9% of methicillin-susceptible S. aureus (MSSA, MIC of MPIPC < 4 μ /ml), 2.5% of methicillin-resistant S. aureus (MRSA, MIC of MPIPC 4 μ /ml), and 7.5% of high-resistance MRSA (MIC of MPIPC ≥ 256 μ /ml). Values of geometric mean for MUP were 0.069 μ /ml for high-resistance MRSA and 0.044 μ /ml for low-resistance MRSA (MIC of MPIPC=4-128 μ /ml). There were significant differences between the geometric means of those MIC values (p < 0.05). Based on theses results, we currently have no problems eradicating S. aureus from the nasal cavity, but must continue to monitor any isolation of high-resistance strains to mupirocin. |
| Keywords |
mupirocin, MRSA |
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