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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
History of Drug-Resistant Microorganisms Associated with Developments of Antimicrobial Agents |
| Language |
J |
| AuthorList |
Masatoshi Konno |
| Affiliation |
Teikyo University |
| Publication |
J.J.C.M.: 14 (1), 1-23, 2004 |
| Received |
March 1, 2004 |
| Accepted |
|
| Abstract |
, in modern medicine, there are many opportunities that foreign substances, such as a catheter, are inserted into the body of patient because the securing of airway to the trachea or lining of the blood vessels are very important. These foreign substances inserted into the body also become a risk-factor for bacterial infection.
The present author has studied about the infectious diseases caused by drug-resistant microorganisms for the duration of 50 years. The research works were also made as a connection with practice of usage of antibiotics and drug-resistant pathogens.
In this paper, five matters occurred step-by-step were mainly described and discussed; (i) prevalence of sulfonamide-resistant Streptococcus pyogenes occurred in the first trial as a preventive usage world wide, (ii) staphylococcal infections due to multidrug resistance which occurred frequently for ten years from about 1955 years, following the periodic prevalence of multidrug-resistant Shigell dysenteriae which became resistance one after another to sulfonamide, tetracycline, and chloramphenicol, (iii) infections caused by gram-negative bacilli including Pseudomonas aeruginosa that were closed up as severe infections from about 1965, (iv) MRSA infections as a hospital-acquired infections that occurred from about 1978, and (v) community-acquired infections caused by penicillin-resistant Streptococcus pneumoniae (PRSP), β -lactamse-nonproducing and ampicillin-resitant Haemophilus influenzae (BLNAR), and fluoroquinolone-resistant Neisseria gonorrhoeae in 1990s.
These problems were discussed in addition to the role of the third-generation cephalosporins and floroquinolone agents lied in the backgrounds. |
| Keywords |
Mutant prevention concentration (MPC) |
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