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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Trends in Nalidixic Acid-resistant Salmonella Typhi and Salmonella Paratyphi A Isolated in Tokyo Metropolitan Bokutoh General Hospital, 1997-2003 |
| Language |
J |
| AuthorList |
Kiyoshi Fuke1), Yukari Harashima1), Yuka Shiuti1), Masako Sakurada1), Machiko Kashiwa1), Kenji Ohnishi2) |
| Affiliation |
1) Department of Clinical Laboratory, Tokyo Metropolitan Bokutoh General Hospital
2) Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital |
| Publication |
J.J.C.M.: 14 (3), 159-163, 2004 |
| Received |
April 26, 2004 |
| Accepted |
August 16, 2004 |
| Abstract |
Eighteen strains of Salmonella Typhi and fourteen strains of Salmonella Paratyphi A that were isolated from typhoid and paratyphoid patients, respectively, from 1997 to 2003 in our hospital. These strains can be divided into two groups by considering reaction with nalidixic acid (NA): NA-resistant and NA-susceptible group. NA-resistant group (8 strains of S. Typhi and 6 strains of S. Paratyphi A) has minimum inhibitory concentrations (MIC) ranged from 0.125 to 1 μ g/ml and can be considered to have a low susceptible to fluoroquinolones. NA-susceptible group received a treatment with fluoroquinolones, while three different treatments were applied to NA-resistant group -six were treated with fluoroquinolones and two were treated with cephems antibiotic and the remains were treated with both fluoroquinolones and cephems antibiotics. NA-susceptible group showed no relapse, while two were observed in NA-resistant group. The average durations of fever after starting the treatment were 3.8 and 6.3 days for NA-susceptible and NA-resistant groups, respectively. The average durations of fever for NA-resistant group, which was treated with only fluoroquinolones was 5.5 days. |
| Keywords |
Salmonella Typhi, Salmonella Paratyphi A, nalidixic acid |
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