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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
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[Vol.14 No.3 contents] Japanese / English |
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| ArticleTitle | Nationwide Survey of Antifungal Drug Susceptibility of Clinical Fungal Isolates in Japan from the Japan Antifungal Surveillance Program (JASP), 2001-2002 |
| Language | J |
| AuthorList | Hideyo Yamaguchi1), Katsuhisa Uchida1), Katsuko Okuzumi2), Toyoko Oguri3), Keiko Adachi4), Sayoko Kawakami5), Masakazu Tosaka6), Chieko Kawashima7), Yoshiko Hori8), Toshimi Kitazawa9), Mutsumu Hayashi10), Yoshihiko Saito11), Kyoko Ozaki12), Yayoi Nishiyama1), Association of Japan Antifungal Susceptibility Surveillance group |
| Affiliation |
1)Teikyo University Institute of Medical Mycology 2)The University of Tokyo Hospital (*Current address: Dokkyo University Hospital) 3)Juntendo University Hospital 4)Tokyo Metropolitan Geriatric Hospital 5)Teikyo University Hospital 6)Kumamoto University Hospital 7)Ashikaga Red Cross Hospital 8)Okayama Saiseikai General Hospital 9)Kitkohkai General Hospital Tane Hospital 10)Jichi Medical School Ohmiya Hospital 11)Tohoku University Hospital 12)Niigata University Hospital |
| Publication | J.J.C.M.: 14 (3), 183-193, 2004 |
| Received | September 14, 2004 |
| Accepted | October 12, 2004 |
| Abstract | We evaluated the antifungal susceptibility profile of 576 recent clinical fungal isolates collected from JASP-participating nationwide hospitals during the two months, June 2001 and March 2002. Almost all isolates were Candida species, with fewer numbers of non-Candida yeasts (16 isolates) and molds (4 isolates). C. albicans was the most frequent species (56.6%), followed by C. glabrata (22.8%), C. tropicalis (9.9%) and C. parapsilosis (3.5%). The MIC of fluconazole (FLCZ), itraconazole, voriconazole and flucytosine against Candida and other yeast species were determined by the Japanese Society for Medical Mycology (JSMM) microdilution method and the NCCLS M27-A2 microdilution method. Percent resistant by using the interpretive breakpoint criteria of NCCLS to FLCZ was 47% for C. tropicalis and around 5% for other Candida species including C. albicans and C. glabrata when tested by JSMM assay method, while the values were lowered to 0 to 4% for all Candida species when tested by the NCCLS M27-A2 protocol. A similar trend was also seen with the two other azole antifungal drugs. A difference in the results obtained between the two assay methods appeared to be due to trailing growth isolates whose azole-susceptibility is usually underestimated in the former method. This study showed that in vitro resistance to these azole antifungal drugs remains uncommon in almost all Candida species. |
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| Copyright © 2002 The Japanese Society for Clinical Microbiology All rights reserved. |