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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
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[Vol.16 No.2 contents] Japanese / English |
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| ArticleTitle | Frequency of Isolation and Susceptibility of Candida Species Isolated from Various Specimens |
| Language | J |
| AuthorList | Takashi Uchida1), Hiromi Fukasawa2), Takeshi Endo1), Mie Mikami3), Toshiko Ohya4), Seitaro Inoue5), Hiroko Yamamoto6) |
| Affiliation |
1) Clinical Laboratory, University of Yamanashi Hospital 2) Bacteriological Examination Room, Yamanashi Kosei Hospital 3) Department of Clinical Laboratory, Kofu Municipal Hospital 4) Department of Inspection, Yamanashi Prefectural Central Hospital 5) Bacteriological Examination Room, Yamanashi Hospital of Social Insurance 6) Department of Inspection, Kofu-Kyoritsu Hospital |
| Publication | J.J.C.M.: 16 (2), 74-80, 2006 |
| Received | September 26, 2005 |
| Accepted | March 8, 2006 |
| Abstract | During the 6 months between October 2003 and March 2004, we examined the frequency of isolation and susceptibility of Candida species isolated from various specimens at 6 facilities in Yamanashi. Sample numbered 9,083, and Candida species was predominantly isolated from 666 isolates (7.3%). 426 strains (64.0%) and 233 strains (35.0%) were Candida albicans and non-albicans Candida species (Candida species except C. albicans), respectively. Among the non-albicans Candida species, the frequency of isolation of Candida glabrata was the highest, followed by Candida tropicalis. Regarding the susceptibility of 659 strains of Candida isolated to antifungal agents, 1 mg/ml of amphotericin B inhibited growth of all strains excluding 1 strain of C. tropicalis. No fluconazole-resistant C. albicans was isolated, but MIC for the non-albicans Candida species distributed from ≤ 0.13 to ≥ 64 μ g/ml, showing the presence of low-susceptible and resistant strains. MIC of micafungin was 0.13 μ g/ml for C. albicans, C. glabrata, and C. tropicalis, and 0.5 μ g/ml for Candida krusei. The MIC90 of amphotericin B, fluconazole and micafungin against all Candida species tested were 0.25 μ g/ml, 4 μ g/ml and 0.06 μ g/ml, respectively. These findings may contribute to the treatment of deep mycosis. |
| Keywords | fluconazole, micafungin |
| Copyright © 2002 The Japanese Society for Clinical Microbiology All rights reserved. |