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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Two Cases of Infantile Diarrhea Caused by Fluoroquinolone-resistant Salmonella Typhimurium |
| Language |
J |
| AuthorList |
Ken-ichi Ogura1), Fuyuhiko Saito1), Koji Morita2) |
| Affiliation |
1) Department of Clinical Laboratory, Tama-Nambu Chiiki Hospital
2) Department of Microbiology, Kyorin University Scool of Health Sciences |
| Publication |
J.J.C.M.: 16 (2), 96-101, 2006 |
| Received |
January 10, 2006 |
| Accepted |
April 27, 2006 |
| Abstract |
Two infants, 7-year-old female and 7-month-old male, were hospitalized because of diarrhea. Stool cultures of both patients were positive for Salmonella Typhimurium with high-level fluoroquinolone-resistance (ciprofloxacin MIC of 16 μ g/ml). They were treated with fosfomycin, and recovered completely. Two S. Typhimurium strains, from above two cases of infantile diarrhea, had some identical features including differentiation of S. Typhimurium strains resistance pattern, plasmid profile, and genotype on randomly amplified polymorphic DNA-PCR. Furthermore, mutations in quinolone resistance-determining regions of GyrA (amino acids change at Ser-83 and Asp-87) and ParC (amino acid change at Ser-80) were also coserved in two S. Typhimurium strains. These results suggest that two infantile diarrhea patients investigated in this case study were infected with the identical clone of fluoroquinolone-resistant S. Typhimurium. Though a conclusive evidence of infection routes were unknown, the pet-related infections were suspected in both cases of infantile diarrhea. Extensive surveillance for fluoroquinolone-resistance Salmonella serovars is necessary. |
| Keywords |
Salmonella Typhimurium |
|
