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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Combined Effects of Antibacterial Agents against Multi-drug Resistant Pseudomonas aeruginosa Detected in Kurume University Hospital |
| Language |
J |
| AuthorList |
Nao Fukushima, Chiyoko Tanamachi, Kouji Hashimoto, Rie Horita, Kazunori Nakata, Kimitaka Sagawa |
| Affiliation |
Department of Laboratory Medicine, Kurume University Hospital,
Asahimachi 67, Kurume, Fukuoka 830-0011, Japan |
| Publication |
J.J.C.M.: 16 (3), 127-133, 2006 |
| Received |
November 18, 2005 |
| Accepted |
July 24, 2006 |
| Abstract |
Thirty-five strains of MDRP (Multi-drug resistant Pseudomonas aeruginosa) identified with Micro Scan Walk Away96 (DADE BEHRING) were isolated, from January 2002 to march 2005 in Kurume University Hospital. Antimicrobial susceptibilities of these strains were re-examined using Etest for various antimicrobial agents. The most effective agent against the strains was ceftazidime (CAZ) (susceptible; 25 strains (71.4%) and resistant; 10 strains (28.6%)). Because these 10 strains did not show susceptibility with any antimicrobial agents, we examined combined effects of antimicrobial agents against these strains by Etest. A combination of cefepime and ciprofloxacin was effective on 4 strains (40%; 1 for synergistic effect, 3 for additive effect) and that of aztreonam (AZT) and amikacin (AMK) was effective to all 10 strains (100%; 7 for synergistic effect, 3 for additive effect). However, five of these 10 strains, produced metallo-β -lactamase, showed high MIC to AMK (32-64 μ g/ml) even in the combination test. Four of the 5 remained strains which did not produce metallo-β -lactamase showed good susceptibilities to the combination of AZT and AMK. These results suggest that although it is difficult to obtain the significant effect against MDRP producing metallo-β -lactamase, the combination of agents is clinically useful for the infectious diseases due to non metallo-β -lactamase producing MDRP. Further studies are needed to find a new effective combination of antimicrobial agents to MDRP-infectious. |
| Keywords |
FIC index |
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