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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Molecular Epidemiology of MRSA Based on MLST and Other Methods |
| Language |
J |
| AuthorList |
Miki Nagao1), Michio Ohta2) |
| Affiliation |
1) Department of Clinical Laboratory and Department of Infection Control and Prevention, Kyoto University Hospital
2) Department of Bacteriology, Nagoya University School of Medicine |
| Publication |
J.J.C.M.: 17 (3), 159-167, 2007 |
| Received |
June 26, 2007 |
| Accepted |
|
| Abstract |
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a leading cause of human diseases in the hospital setting as well as in the community, accounting for a wide variety of diseases. Because this pathogen can be a transient component of nose and skin flora of the human and easily transmits by contact, it is crucial to know its epidemiology to break a chain of infection. The advancement in molecular biology has led to the technological development of gene analysis, which has brought about a great breakthrough in the field of bacterial molecular epidemiology. The epidemiology of MRSA has been investigated by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), spa typing and SCCmec typing. By combining these methods, interesting facts about the global distribution of MRSA and its evolution have been revealed. This review summarizes the outline of these epidemiologic methods and the latest molecular epidemiological knowledge about MRSA with emphasizing a focus on MLST. |
| Keywords |
MRSA, MLST, PFGE, spa typing |
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