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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Three Children with Bacterial Meningitis Due to Drug-Resistant Strains Haemophilus influenzae Type b |
| Language |
J |
| AuthorList |
Izumi Kurita1), Kyouko Nishitani1), Yumi Tsuchida1), Kozo Mutoh2) |
| Affiliation |
1) Clinical Laboratory Medicine, Shimada Municipal Hospital
2) Department of Pediatrics, Shimada Municipal Hospital |
| Publication |
J.J.C.M.: 17 (3), 168-176, 2007 |
| Received |
November 16, 2006 |
| Accepted |
May 16, 2007 |
| Abstract |
We here report on 3 children with bacterial meningitis due to drug-resistant strains of Haemophilus influenzae type b (Hib), who visited our hospital in a 13-month period stemming from July 2004 to July 2005. Gene analysis of isolated strains exhibited that Cases 1 and 2 had β-lactamase producing amoxicillin clavulanate resistant H. influenzae (BLPACR-II), and that Case 3 suffered from β-lactamase non-producing ampicillin resistant H. influenzae (BLNAR). Drug-resistance of Hib is increasing also in our area, so rapid identification of Hib in the CSF contributed greatly to selecting appropriate antibiotics (meropenem and cefpirome) in each case. They all responded excellently to the antibiotics and dexamethasone, and recovered without neurological sequelae. |
| Keywords |
Haemophilus influenzae, BLNAR, BLPACR |
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