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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
The Survy of Methicillin-resistant Staphylococcus aureus Nasal Cultures in the Hosptal during Past 7 Years |
| Language |
J |
| AuthorList |
Yoshito Tsujihara1), Tadashi Honma1), Kouji Yoshikawa2), Iwao Sakurai2), Mikiko Yamada3) |
| Affiliation |
1) Department of Clinical Laboratory, Kanagawa Prefectural Shiomidai Hospital
2) Department of Internal Medicine, Kanagawa Prefectural Shiomidai Hospital
3) Department of Clinical Laboratory, Yokohama City Institute of Health |
| Publication |
J.J.C.M.: 18 (1), 8-14, 2008 |
| Received |
July 4, 2007 |
| Accepted |
November 28, 2007 |
| Abstract |
In our hospital we perform nasal cultures on admission of patients to control infection in the hospital. We investigated the status of the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the nasal cavity during the 7 years from January 2000 to December 2006. A total of 5,534 patients were examined during this period. Of these patients, 259 had a positive culture for MRSA (prevalence, 4.7%). Eradication with mupirocin (MUP) was attempted in 112 of the 259 patients. MUP was used in 43.2% of the patients. To assess the effectiveness of this eradication therapy, we performed nasal cultures in 58 of the 112 patients (51.8%) after completion of treatment with MUP. Eradication was achieved in 34 of the 58 patients (58.6%). Furthermore, the strain which has high similarity was detected from 4 persons among 7 persons who were able to examine the genomic homogeny of MRSA detected at the time of primary hospitalization and re-hospitalization. It is controversial whether eradication therapy should be performed in all patients, but the finding that laboratory cultures were performed only in 51.8% of the patients for the assessment of the effectiveness of this eradication therapy with MUP indicates that there was a problem in the treatment measures after admission. The present study suggests that a strategy for eradication therapy against so-called carried-in MRSA should be established in the future. |
| Keywords |
methicillin resistant Staphylococcus aureus, mupirocin, pulsed field gel electrophoresis |
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