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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
A Case of Typhoid Fever Due to Fluoroquinolone-Resistant Salmonella Typhi |
| Language |
J |
| AuthorList |
Misa Suzuki1), Naoki Sugimoto2) |
| Affiliation |
1) Department of Clinical Laboratory, Shizuoka Saiseikai General Hospital
2) Department of Clinical Laboratory, Shizuoka City Hospital |
| Publication |
J.J.C.M.: 18 (3), 189-192, 2008 |
| Received |
March 4, 2008 |
| Accepted |
June 2, 2008 |
| Abstract |
We report a case of typhoid fever due to fluoroquinolone-resistant Salmonella Typhi occurring in a 23-year-old male traveler, who returned to Japan from Thailand and India. The culture of both his blood and stool specimens yielded growths of S. Typhi colonies. Susceptibility tests revealed that the isolate was resistant to fosfomycin (FOM) and to quinolone drugs. Therefore, the initial chemotherapy with FOM, levofloxacin (LVFX), ampicillin (ABPC) and sulbactam/cefoperazone (SBT/CPZ) upon his hospitalization was changed to sulfamethoxazole/trimethoprim (ST) and ceftriaxone (CTRX). His symptoms rapidly disappeared and he recovered soon. Subsequent PCR analysis disclosed that the genes responsible for the resistance to quinolones were due to the mutations of gyrA and parC. To our knowledge, this is the first case report in Japan of a person infected with fluoroquinolone-resistant S. Typhi. |
| Keywords |
Salmonella Typhi |
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