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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Evaluation of Antibacterial Activity of Newer Respiratory Quinolones against Streptococcus pneumoniae |
| Language |
J |
| AuthorList |
Shigeru Fukuzawa1), Kazuhiro Tateda*1,2), Yoshikazu Ishii1,2), Kyoko Enokizono1), Ayumi Hikosaka1), Rie Shibuya2), Chikako Maehara1), Hinako Murakami1), Kumiko Yasui1), Shigeo Yumoto1), Morihiro Iwata1), Keizo Yamaguchi1,2) |
| Affiliation |
1) Laboratory of Microbiology in Ohmori Hospital, Toho Medical Center
2) Department of Microbiology and Infectious Diseases, Toho University School of Medicine
* Corresponding author |
| Publication |
J.J.C.M.: 19 (1), 21-25, 2009 |
| Received |
February 29, 2008 |
| Accepted |
January 14, 2009 |
| Abstract |
Antimicrobial susceptibility testing of newer quinolones, including developing agents, was performed against 356 strains of Streptococcus pneumoniae isolated in our hospital. Approximately 60% of strains demonstrated less susceptible to penicillin-G. To clarithromycin, 264 strains (74.2%) were classified to be resistant, while 9 strains (2.5%) exhibited MIC of 2 μg/ml to telithromycin. MIC90 (μg/ml) of quinolones were as follows: DX619 (0.031 or less), garenoxacin (0.063), sitafloxacin (0.063), tosfloxacin (0.25), moxifloxacin (0.25), gatifloxacin (0.5), levofloxacin (1), ciprofloxacin (2), pazufloxacin (2). Pulse-field gel electrophoresis analysis using levofloxacin or telithromycin less susceptible strains demonstrated no evidence of wide spreading of antibiotic resistant clone in our hospital. These data suggest efficacy of newer respiratory quinolones against S. pneumoniae infections, and further support need of continuous surveillance for appearance and spreading of antibiotic resistance organisms. |
| Keywords |
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