 |
 |
 |
The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
|
[Vol.19 No.3 contents] Japanese / English |
|
| ArticleTitle | Nationwide Survey of Antifungal Drug Susceptibility of Clinical Fungal Isolates in Japan for the Japan Antifungal Surveillance Program (JASP), 2005 |
| Language | J |
| AuthorList | Hideyo Yamaguchi1), Yayoi Nishiyama1), Katsuhisa Uchida1), Choichiro Takahashi2), Chieko Kawashima3), Mutsumu Hayashi4), Sayoko Kawakami5), Keiko Adachi6), Katsuko Okuzumi7), Yoshiki Misawa8), Toyoko Oguri9), Yukie Okimura10), Toshimi Kitazawa11), Yoshiko Hori12), Masakazu Tosaka13), (Association of Japan Antifungal Susceptibility Surveillance) |
| Affiliation |
1) Teikyo University Institute of Medical Mycology 2) Yamagata University Hospital 3) Ashikaga Red Cross Hospital 4) Saitama Medical Center Jichi Medical University 5) Teikyo University Hospital 6) Tokyo Metropolitan Geriatric Hospital 7) Dokkyo University Hospital 8) The University of Tokyo Hospital 9) Juntendo University Hospital (Current address: Kameda Medical Center) 10) Shinshu University Hospital 11) Kikkoukai General Hospital Tane Hospital 12) Okayama Saiseikai General Hospital 13) Kumamoto University Hospital |
| Publication | J.J.C.M.: 19 (3), 128-141, 2009 |
| Received | November 21, 2008 |
| Accepted | May 1, 2009 |
| Abstract | As a third nationwide surveillance of the longitudinal Japanese Antifungal Surveillance Program (JASP), a total of 541 Candida isolates, 17 non-Candida yeast isolates, and 18 Aspergillus isolates collected in 11 hospitals during 2 months, June and July 2005, were studied for their in vitro antifungal susceptibilities. The rank order of Candida spp. occurrence was as follows: C. albicans (57.8%), C. glabrata (18.6%), C. tropicalis (8.0%), C. parapsilosis (4.7%) and C. krusei (2.4%). Percent resistant by using the interpretive breakpoint criteria of CLSI guideline to fluconazole (FLCZ), itraconazole (ITCZ) and voriconazole (VRCZ) was 7.5, 9.3 and 1.9% for C. glabrata and 93, 14 and 14% for C. krusei, respectively. In other Candida spp., isolates resistant to any of the three azoles drugs were not or only infrequently detected. All Candida spp. isolates were favorably susceptible to 5-FC. All of 17 A. fumigatus isolates were susceptible to both ITCZ and VRCZ except one isolate insusceptible only to ITCZ (MIC, > 8 μg/ml). These results which extend upon previous finding from JASP reports (2001 to 2003) suggest a changing trend of frequency of resistance for Candida spp. isolates and emphasize the importance of continuing this or a similar type of surveillance. |
| Keywords |
| Copyright © 2002 The Japanese Society for Clinical Microbiology All rights reserved. |