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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Evaluation of Four Quinolones against Fluoroquinolone-nonsusceptible Clones of Streptococcus pneumoniae and Haemophilus influenzae |
| Language |
J |
| AuthorList |
Shin-ichi Yokota, Yasuo Ohkoshi, Nobuhiro Fujii* |
| Affiliation |
Department of Microbiology, Sapporo Medical University School of Medicine
* Corresponding author |
| Publication |
J.J.C.M.: 21 (1), 17-24, 2011 |
| Received |
August 4, 2010 |
| Accepted |
December 2, 2010 |
| Abstract |
We evaluated activity of 4 quinolones against conventional-fluoroquinolone-nonsusceptible and susceptible clinical isolates of Streptococcus pneumoniae and Haemophilus influenzae derived from various clinical sources in Japan. Bactericidal activity under concentration of Cmax or free Cmax against S. pneuminiae occurred in order of garenoxacin>sitafloxacin>moxifloxacin>levofloxacin. Garenoxacin was most rapidly bactericidal for S. pneumoniae, including fluoroquinolone-nonsusceptible strains. AUC/MIC ratios of garenoxacin to all S. pneumoniae strains tested were highest among the 4 quinolones, and above the target value (30 to 40) for bacterial eradication. Serotypes of the fluoroquinolone-nonsusceptible S. pneumoniae strains were relatively rare ones. Fluoroquinolone-nonsusceptible H. influenzae strains were suggested to expand clonally in Sapporo-city (Hokkaido Prefecture, Japan). Three clones (8 strains, 3 strains and 1 strain of each clone) shared 3 to 5 mutations in quinolone resistance determining region of quinolone target genes. STFX showed the least MIC values among 4 quinolones, however, no quinolones showed exceeded target value of AUC/MIC ratio (100 to 125) for bacterial eradication of H. influenzae to former 2 clones. In conclusion, garenoxacin, which shared high susceptibility to S. pneumoniae and high AUC value, is expected to have high therapeutic activity against S. pneumoniae strains including resistant strains to conventional fluoroquinolones. |
| Keywords |
PK/PD |
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