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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Emergence and evolution of microbial drug-resistance |
| Language |
J |
| AuthorList |
Hajime Hashimoto1), Somay Yamagata Murayama2) |
| Affiliation |
1Department of Microbiology, School of Medicine, Gunma University
2Laboratory of Molecular Cell Biology, School of Pharmacy, Nihon University |
| Publication |
J.J.C.M.: 23 (1), 1-11, 2013 |
| Received |
January 31, 2013 |
| Accepted |
|
| Abstract |
Resistant-bacteria emerge when the concentration of drug in the blood is kept for a long time among the MSW (Mutant Selection Window, between MIC of sensitive and resistant bacteria). Antibiotic resistance can be a result of a point mutation in the endogenous pathogen genome, or of horizontal transfer of exogenous genes by transformation, transduction, or conjugation. It has been suggested that the origin of these exogenous genes are self-defense mechanism in antibiotic-producing organisms, such as actinomycetes. The low concentration of most antibiotics, like other small molecules, was found to regulate the expression of many genes. The original role of antibiotics might be not only intercellular communication but also an important factor for intracellular regulation. Acquisition of drug-resistance by pathogenic bacteria may reflect the general mode of genome evolution to adapt itself for various environmental changes. |
| Keywords |
MSW, parvome |
|
