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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
The molecular mechanisms of severe invasive group A Streptococcus infections |
| Language |
J |
| AuthorList |
Manabu Ato1), Tadayoshi Ikebe2), Haruo Watanabe3) |
| Affiliation |
1) Department of Immunology, National Institute of Infectious Disease
2) Department of Bacteriology I, National Institute of Infectious Disease
3) Director-General, National Institute of Infectious Disease |
| Publication |
J.J.C.M.: 23 (2), 79-86, 2013 |
| Received |
May 2, 2013 |
| Accepted |
|
| Abstract |
Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock and multiorgan failure; it has a high mortality rate. Although a number of studies have attempted to determine the crucial genetic changes behind the onset of STSS, the responsible genes in group A Streptococcus (GAS) have not been clarified. We have been established a panel of clinical isolates from Japanese patients for more than 20 years, collaborating with Working Group for Beta-hemolytic Streptococci in Japan. We identified that mutations in the negative regulators csrS/csrR and rgg of GAS are crucial factors in the pathogenesis of STSS, as they lead to the overproduction of multiple virulence factors. In addition, severe invasive GAS infections hampered host innate immune defense, especially on PMN, which provide the front-line defense against GAS infection. We further discuss a perspective on the control of STSS in the future. |
| Keywords |
streptococcal toxic shock-like syndrome, pathogenic factors, two-components regulatory system, neutrophil |
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