 |
The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Functional classification of the β-lactamases |
| Language |
J |
| AuthorList |
Yoshikazu Ishii |
| Affiliation |
Division of Infection Control and Prevention, Department of Microbiology and Infectious Diseases, Toho University School of Medicine |
| Publication |
J.J.C.M.: 24 (3), 171-179, 2014 |
| Received |
July 25, 2014 |
| Accepted |
|
| Abstract |
The β-lactam antibiotics play an important role in antibacterial chemotherapy because of their high efficacy combined with a lack of toxicity exception of allergy. First article concerning β-lactamase in Bacillus coli was reported by Abraham and Chain by 1940. Now, most of clinical physicians, clinical technologists, pharmacists and nurses have known that resistance to β-lactams in Gram-negative organisms are associated with plasmid which are easily transferred among species. β-Lactam resistance caused by β-lactamase is increasingly associated with plasmidic AmpC, extended-spectrum β-lactamases (ESBLs) and carbapenemases, specifically the CMY-family of AmpC, the CTX-M-family of ESBLs, the KPC family of serine carbapenemases, and the IMP, VIM and NDM-1 metallo-β-lactamases. Classification of the β-lactamase is quite complicated, because more than 1500 β-lactamases have been reported now. In this review, I will try to update and explain of the classification for β-lactamase. |
| Keywords |
β-lactamase, classification, function |
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